Maurocalcine: toxin properties
Maurocalcine is a component of the venom of Scorpio maurus palmatus. It folds according to an inhibitor cysteine knot. It is a new member of the family of toxins acting on ryanodine receptors with an affinity in the 10 nM range. It induces an increase in channel opening probability accompanied by sudden transitions to long lasting subconductance states. It has also been characterized as a cell penetrating peptide and its pharmacological activity can be observed upon extracellular perfusion.
Product Specification
AA sequence: H-Gly-Asp-Cys3-Leu-Pro-His-Leu-Lys-Leu-Cys10-Lys-Glu-Asn-Lys-Asp-Cys16-Cys17-Ser-Lys-Lys-Cys21-Lys-Arg-Arg-Gly-Thr-Asn-Ile-Glu-Lys-Arg-Cys32-Arg-OH
(Disulfide bonds between Cys3-Cys17, Cys10-Cys21 and Cys16-Cys32)
Length (aa): 33
Formula: C156H260N56O46S6
Molecular Weight: 3858.8 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: not available
Source: Synthetic
Purity rate: > 98 %
Price & Quantities
- 10 µg : 110 €
- 50 µg : 180 €
- 100 µg : 300 €
- 500 µg : 750 €
- 1 mg : 1275 €
Other quantities available upon request
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References
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Fajloun, Z., Kharrat, R., Chen, L., Lecomte, C., Di Luccio, E., Bichet, D., El Ayeb, M., Rochat, H., Allen, P. D., Pessah, I. N., De Waard, M., and Sabatier, J. M. (2000) Chemical synthesis and characterization of maurocalcine, a scorpion toxin that activates Ca(2+) release channel/ryanodine receptors, FEBS Lett 469, 179-185.
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Mosbah, A., Kharrat, R., Fajloun, Z., Renisio, J. G., Blanc, E., Sabatier, J. M., El Ayeb, M., and Darbon, H. (2000) A new fold in the scorpion toxin family, associated with an activity on a ryanodine-sensitive calcium channel, Proteins40, 436-442.