ω-CONOTOXIN GVIA
Catalog N: 08CON003
ω-conotoxin GVIA: toxin properties
ω-conotoxin GVIA has been isolated from the venom of the cone Conus geographus. Omega-conotoxin GVIA acts at presynaptic membranes. It binds and blocks specifically Cav2.2 channel with an ED50 of 68pM.
Product description
AA sequence: H-Cys1-Lys-Ser-Hyp-Gly-Ser-Ser-Cys8-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys15-Cys16-Arg-Ser-Cys19-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys26-Tyr-NH2
Hyp: hydroxyproline
(Disulfide bonds between Cys1-Cys16, Cys8-Cys19 and Cys15-Cys26)
Length (aa): 27
Formula: C120H182N38O43S6
Molecular Weight: 3036.05 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: [106375-28-4]
Source: Synthetic
Purity rate: > 95 %
Price & Quantities
-
100 µg : 130 €
-
500 µg : 325 €
Other quantities available upon request.
Related products
___________________________________________________________________________
References
-
Lew, M. J., et al. (1997) Structure-function relationships of omega-conotoxin GVIA. Synthesis, structure, calcium channel binding, and functional assay of alanine-substituted analogues, J Biol Chem 272, 12014-12023. PubMed link
-
Seiji Ichida, et al. (2005) Characteristics of Omega-conotoxin GVIA and MVIIC Binding to Cav 2.1 and Cav 2.2 Channels Captured by Anti-Ca2+ Channel Peptide Antibodies, Neurochemical Research 30, 457-466. PubMed link
-
Schroeder Cl., et al. (2006) N-type calcium channel blockers: novel therapeutics for the treatment of pain. Med Chem. Sep;2(5):535-43. PubMed link