Maurotoxin 
Maurotoxin: toxin properties
Maurotoxin is a component of the venom of Scorpio maurus palmatus.This toxin is a member of the α-KTx6.2 scorpion toxin family. It blocks voltage-gated potassium channels (KV1.1/KCNA1, KV1.2/KCNA2, and KV1.3/KCNA3) and inhibits apamin-sensitive small conductance calcium-activated channels (SK channels), particularly KCa3.1 (IKca1, SK4). The blockage of Kv1.2 occurs with high affinity.
Product Specification
AA sequence: H-Val-Ser-Cys3-Thr-Gly-Ser-Lys-Asp-Cys9-Tyr-Ala-Pro-Cys13-Arg-Lys-Gln-Thr-Gly-Cys19-Pro-Asn-Ala-Lys-Cys24-Ile-Asn-Lys-Ser-Cys29-Lys-Cys31-Tyr-Gly-Cys34-NH2
(Disulfide bonds between Cys3-Cys24, Cys9-Cys29, Cys13-Cys19 and Cys31 -Cys34)
Length (aa): 34
Formula: C145H231N45O47S8
Molecular Weight: 3612.55 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: not available
Source: Synthetic
Purity rate: > 95 %
Price & Quantities
- 100 µg : 200 €
- 500 µg : 700 €
- 1 mg : 1190 €
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References
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Fajloun Z, Andreotti N, Fathallah M, Sabatier JM, De Waard M., (2011) Analysis of the interacting surface of maurotoxin with the voltage-gated Shaker B K(+) channel. J Pept Sci. 2011 Mar;17(3):200-10
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Carlier, E., Avdonin, V., Geib, S., Fajloun, Z., Kharrat, R., Rochat, H., Sabatier, J. M., Hoshi, T., and De Waard, M. (2000) Effect of maurotoxin, a four disulfide-bridged toxin from the chactoid scorpion Scorpio maurus, on Shaker K+ channels, J Pept Res 55, 419-427.
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Rochat, H., Kharrat, R., Sabatier, J. M., Mansuelle, P., Crest, M., Martin-Eauclaire, M. F., Sampieri, F., Oughideni, R., Mabrouk, K., Jacquet, G., Van Rietschoten, J., and El Ayeb, M. (1998) Maurotoxin, a four disulfide bridges scorpion toxin acting on K+ channels, Toxicon 36, 1609-1611.
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Blanc, E., Sabatier, J. M., Kharrat, R., Meunier, S., el Ayeb, M., Van Rietschoten, J., and Darbon, H. (1997) Solution structure of maurotoxin, a scorpion toxin from Scorpio maurus, with high affinity for voltage-gated potassium channels, Proteins 29, 321-333.
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Kharrat, R., Mabrouk, K., Crest, M., Darbon, H., Oughideni, R., Martin-Eauclaire, M. F., Jacquet, G., el Ayeb, M., Van Rietschoten, J., Rochat, H., and Sabatier, J. M. (1996) Chemical synthesis and characterization of maurotoxin, a short scorpion toxin with four disulfide bridges that acts on K+ channels, Eur J Biochem 242, 491-498.