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Sarafotoxin A

Catalog N : 08SAR001
 

Sarafotoxin A :toxins properties

Sarafotoxin A has been isolated from the venom of the Snake Atractaspis engaddensis. This toxin demonstrates vasoconstrictor activity. The compound has a close structural homology to the endothelin family. Sarafotoxin A causes cardiac arrest probably as a result of coronary vasospasm. LD50 is 0.015 mg/kg by intravenous injection for sarafotoxin A.

Product Specification

AA sequence: H-Cys1-Ser-Cys3-Lys-Asp-Met-Ser-Asp-Lys-Glu-Cys11-Leu-Asn-Phe-Cys15-His-Gln-Asp-Val-Ile-Trp-OH
(Disulfide bonds between Cys1-Cys15 and Cys3-Cys11)
Length (aa): 21
Formula: C104H154N28O34S5
Molecular Weight: 2502.21 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: [126738-34-9]
Source: Synthetic
Purity rate: > 95 %

Price & quantities

  • 100 µg : 100 €
  • 500 µg : 250 €
  • 1 mg : 425 €
  Other quantities available upon request
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 References

  • Ducancel, F., Matre, V., Dupont, C., Lajeunesse, E., Wollberg, Z., Bdolah, A., Kochva, E., Boulain, J. C., and Menez, A. (1993) Cloning and sequence analysis of cDNAs encoding precursors of sarafotoxins. Evidence for an unusual "rosary-type" organization, J Biol Chem 268, 3052-3055.
  • Mills, R. G., Atkins, A. R., Harvey, T., Junius, F. K., Smith, R., and King, G. F. (1991) Conformation of sarafotoxin-6b in aqueous solution determined by NMR spectroscopy and distance geometry, FEBS Lett 282, 247-252.
  • Aimoto, S., Hojoh, H., and Takasaki, C. (1990) Studies on the disulfide bridges of sarafotoxins. Chemical synthesis of sarafotoxin S6B and its homologue with different disulfide bridges, Biochem Int 21, 1051-1057.
  • Kloog, Y., Ambar, I., Sokolovsky, M., Kochva, E., Wollberg, Z., and Bdolah, A. (1988) Sarafotoxin, a novel vasoconstrictor peptide: phosphoinositide hydrolysis in rat heart and brain, Science 242, 268-270.
  • Takasaki, C., Tamiya, N., Bdolah, A., Wollberg, Z., and Kochva, E. (1988) Sarafotoxins S6: several isotoxins from Atractaspis engaddensis (burrowing asp) venom that affect the heart, Toxicon 26, 543-548.

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