E-mail Print PDF

SNX482


Catalog N : 08SNX001

SNX 482: toxin properties

SNX-482 has been isolated from the venom of the Spider Hysterocrates gigas (African tarantula). This toxin modulates the R-type current associated with the class α1E calcium channel (Cav2.3 from the CACNA1E gene). SNX-482 antagonizes channel activation by inducing a depolarizing shift in the activation potential, thus preventing the channel from undergoing normal membrane depolarization. SNX-482 acts rapidly and maintains its effect.

Product Specification

AA sequence: H-Gly-Val-Asp-Lys-Ala-Gly-Cys7-Arg-Tyr-Met-Phe-Gly-Gly-Cys14-Ser-Val-Asn-Asp-Asp-
Cys20-Cys21-Pro-Arg-Leu-Gly-Cys26-His-Ser-Leu-Phe-Ser-Tyr-Cys33-Ala-Trp-Asp-Leu-Thr-Phe-Ser-Asp-OH
(Disulfide bonds between Cys7-Cys21, Cys14-Cys26 and Cys20-Cys33)
Length (aa): 41
Formula: C192H274N52O60S7
Molecular Weight: 4496.42 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: 203460-30-4
Source: Synthetic
Purity rate: > 90 %

Price & Quantities

  • 50 µg : 140 €
  • 100 µg : 240 €

Other quantities available upon request

Related products

ω-conotoxin MVIIA

ω-conotoxin GVIA

ω-agatoxin IVA

ω-conotoxin SO3

ω-conotoxin MVIIC
___________________________________________________________________________

References

  • Bourinet, E., et al. (2001) Interaction of SNX482 with domains III and IV inhibits activation gating of alpha(1E) (Ca(V)2.3) calcium channels, Biophys J81, 79-88.
  • Newcomb, R., et al. (1998) Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas, Biochemistry 37, 15353-15362.

ADD_WISH