Apamin
Apamin: toxin properties
Apamin is a neurotoxin that was originally isolated from Apis mellifera. Apamin binds to and inhibits the SK channels (small conductance Ca2+-activated K+ channels) in the brain and spinal cord. It inhibits three subtypes of SK channels (SK1, SK2, and SK3) with different affinity. Apamin most likely acts as a pore blocker, although residues both inside and outside of the pore region of the SK channels participate in0 apamin binding. The SK channels are present in a wide range of excitable and non-excitable cells, including cells in the central nervous system, intestinal myocytes, endothelial cells, and hepatocytes.
Product Specification
AA sequence: H-Cys1-Asn-Cys3-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys11-Ala-Arg-Arg-Cys15-Gln-Gln-His-NH2
(Disulfide bonds between Cys1-Cys11 and Cys3-Cys15)
Length (aa): 18
Formula: C79H131N31O24S4
Molecular Weight: 2027.34 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: [24345-16-2]
Source: Synthetic
Purity rate: > 98 %
Prices & quantities
- 500µg : 110 €
- 1mg : 190 €
Other quantities available upon request
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References
- Habermann E (1984). Apamin. Pharmacol Ther. 1984;25(2):255-70. PubMed Link
- Strong PN (1990). Potassium channel toxins. Pharmacol Ther. 1990;46(1):137-62.PubMed link
- Castle NA. Haylett DG. and Jenkisson DH. Toxins in the characterization of potassium channels Trends Neurosci 12 59-65 (1989). PubMed link