α-Conotoxin MI
Catalog N : 08CON012
α-conotoxin MI: toxin properties
α-conotoxin MI has been isolated from the venom of the cone snail Conus magus. This conotoxin acts on postsynaptic membranes. It binds onto and blocks nicotinic acetylcholine receptors (nAChR). α-conotoxin MI blocks mammalian nAChR composed of α1/δ subunits with high potency and α1/γ with low potency.
Product Specification
AA sequence: H-Gly-Arg-Cys3-Cys4-His-Pro-Ala-Cys8-Gly-Lys-Asn-Tyr-Ser-Cys14-NH2
(Disulfide bonds between Cys3-Cys8 and Cys4-Cys14)
Length (aa): 14
Formula: C58H88N22O17S4
Molecular Weight: 1495.08 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: [83481-45-2]
Source: Synthetic
Purity rate: > 67 %
Price & Quantities
- 500 µg : 150 €
- 1 mg : 255 €
Other quantities available upon request
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References
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Jacobsen, R. B., et al. (1999) Critical residues influence the affinity and selectivity of alpha-conotoxin MI for nicotinic acetylcholine receptors, Biochemistry 38, 13310-13315. PubMed link
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Gray, W. R., et al. (1983) Conotoxin MI. Disulfide bonding and conformational states, J Biol Chem 258, 12247-12251. PubMed link
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Papineni RV, et al. (2001) Site-specific charge interactions of alpha-conotoxin MI with the nicotinic acetylcholine receptor. J Biol Chem. 2001 Jun 29;276(26):23589-98. Epub 2001 Apr 25. PubMed link