HsTx1

HsTx1: toxin properties

HsTx1 is a member of the a-KTx6 family of toxins active on voltage-gated K⁺_v1.3 channels (K_d close to 10 pM). It is also very active on K_v1.2 channels (Kd around 7 nM). It is however inactive on apamin-sensitive SK channels. It is one of the most potent toxins active on K

Product Specification

AA sequence: H-Ala-Ser-Cys³-Arg-Thr-Pro-Lys-Asp-Cys⁹-Ala-Asp-Pro-Cys¹³-Arg-Lys-Glu-Thr-Gly-Cys¹⁹-Pro-Tyr-Gly-Lys-Cys²⁴-Met-Asn-Arg-Lys-Cys²⁹-Lys-Cys³¹-Asn-Arg-Cys³⁴-NH₂
(Disulfide bonds between Cys³-Cys²⁴, Cys⁹-Cys²⁹, Cys¹³-Cys³¹ and Cys¹⁹-Cys³⁴)
Length (aa): 34
Formula: C₁₄₉H₂₄₆N₅₄O₄₆S₉
Molecular Weight: 3819.87 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: not available
Source: Synthetic
Purity rate: > 95 %

Price & Quantities

Other quantities available upon request

Related products

___________________________________________________________________________

References

• Savarin, P., et al. (1999) Structural and functional consequences of the presence of a fourth disulfide bridge in the scorpion short toxins: solution structure of the potassium channel inhibitor HsTX1, Protein Sci 8, 2672-2685.
• Lebrun, B., et al. (1997) A four-disulphide-bridged toxin, with high affinity towards voltage-gated K+ channels, isolated from Heterometrusspinnifer (Scorpionidae) venom, Biochem J328 ( Pt 1), 321-327.

ADD_WISH