Margatoxin 
Catalog N : 08MAG001
Margatoxin: toxin properties
Margatoxin is a component of the venom of Scorpio Centruroides margaritatus. This toxin is a potent selective inhibitor of voltage-dependent potassium channels such as Kv1.3.
Product Specification
AA sequence: H-Thr-Ile-Ile-Asn-Val-Lys-Cys7-Thr-Ser-Pro-Lys-Gln-Cys13-Leu-Pro-Pro-Cys17-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys29-Met-Asn-Gly-Lys-Cys34-Lys-Cys36-Tyr-Pro-His-OH
(Disulfide bonds between Cys7-Cys29, Cys13-Cys34 and Cys17-Cys36)
Length (aa): 39
Formula: C178H286N52O50S7
Molecular Weight: 4179.03 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: [145808-47-5]
Source: Synthetic
Purity rate: > 97 %
Price & Quantities
- 100 µg : 160 €
- 500 µg : 400 €
- 1 mg : 680 €
Other quantities available upon request
Related products
| Kaliotoxin 1 | ShK | HsTx1 | Maurotoxin |
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References
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Bednarek, M. A., et al. (1994) Chemical synthesis and structure-function studies of margatoxin, a potent inhibitor of voltage-dependent potassium channel in human T lymphocytes, Biochem Biophys Res Commun 198, 619-625.
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Johnson, B. A., et al. (1994) Determination of the three-dimensional structure of margatoxin by 1H, 13C, 15N triple-resonance nuclear magnetic resonance spectroscopy, Biochemistry 33, 15061-15070.
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Garcia-Calvo, et al. (1993) Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels, J Biol Chem 268, 18866-18874.