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ω-Conotoxin MVIIC mviic1



Catalog N : 08CON002


ω-Conotoxin MVIIC: toxin properties

ω-conotoxin MVIIC has been isolated from the venom of the cone Conus magus. ω-conotoxin MVIIC inhibits presynaptic Ca2+ channels, including the Ca2+ channels responsible for Ca2+ uptake by rat brain synaptosomes, the P-type Ca2+ channels in cerebellar Purkinje cells, and a significant fraction of ω-conotoxin GVIA-resistant currents in hippocampal CA1 neurons. ω-conotoxin MVIIC also presents an inhibition of ω-conotoxin GVIA-resistant depolarization-induced neurotransmitter release in cerebellar neurons of rats.

Product Specification

AA sequence: H-Cys1-Lys-Gly-Lys-Gly-Ala-Pro-Cys8-Arg-Lys-Thr-Met-Tyr-Asp-Cys15-Cys16-Ser-Gly-Ser-Cys20-Gly-Arg-Arg-Gly-Lys-Cys26-NH2
(Disulfide bonds between Cys1-Cys16, Cys8-Cys20 and Cys15-Cys26)
Length (aa): 26
Formula: C106H178N40O32S7
Molecular Weight: 2750.20 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: [147794-23-8]
Source: Synthetic
Purity rate: > 97 %

Price & Quantities

  • 100 µg : 120 €
  • 500 µg : 300 €
  • 1 mg : 510 €

Other quantities available upon request

Related products

ω-conotoxin MVIIA

ω-conotoxin GVIA

ω-agatoxin IVA

ω-conotoxin SO3

SNX482
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References

  • Hillyard, D. R., et al. (1992) A new Conus peptide ligand for mammalian presynaptic Ca2+ channels, Neuron 9, 69-77. PubMed link
  • Woppmann A, (1994) Calcium channel subtypes in rat brain: biochemical characterization of the high-affinity receptors for omega-conopeptides SNX-230 (synthetic MVIIC), SNX-183 (SVIB), and SNX-111 (MVIIA). Mol Cell Neurosci. 1994 Aug;5(4):350-7. PubMed link
  • Grantham CJ, (1994) Omega-conotoxin MVIIC reve rsibly inhibits a human N-type calcium channel and calcium influx into chick synaptosomes. Neuropharmacology. 1994 Feb;33(2):255-8. PubMed link

 

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