Agelenin
Catalog N : 08AGE001
Agelenin: toxin properties
Agelenin has been isolated from the venom of the Agelenidae spider Agelena opulenta. This toxin suppresses the excitatory postsynaptic potentials possibly by blocking the presynaptic calcium channel.
Product Specification
AA sequence : H-Gly-Gly-Cys3-Leu-Pro-His-Asn-Arg-Phe-Cys10-Asn-Ala-Leu-Ser-Gly-Pro-Arg-Cys18-Cys19- Ser-Gly-Leu-Lys-Cys24-Lys-Glu-Leu-Ser-Ile-Trp-Asp-Ser-Arg-Cys34-Leu-NH2
(Disulfide bonds between Cys3-Cys19, Cys10-Cys24 and Cys18-Cys34)
Length (aa): 35
Formula: C160H254N52O45S6
Molecular Weight: 3819.85 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number:
Source: Synthetic
Purity rate: > 95 %
Price & Quantities
- 100 µg : 150 €
- 500 µg : 375 €
- 1 mg : 640 €
Other quantities available upon request
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References
- Yamaji, N., Sugase, K., Nakajima, T., Miki, T., Wakamori, M., Mori, Y., and Iwashita, T. (2007) Solution structure of agelenin, an insecticidal peptide isolated from the spider Agelena opulenta, and its structural similarities to insect-specific calcium channel inhibitors, FEBS Lett 581, 3789-3794.
- Inui, T., Hagiwara, K., Nakajima, K., Kimura, T., Nakajima, T., and Sakakibara, S. (1992) Synthesis and disulfide structure determination of agelenin: identification of the carboxy-terminus as an amide form, Pept Res 5, 140-144.