α Conotoxin IMI
Catalog N : 08CON011
α-conotoxin IMI: toxin properties
α-conotoxin IMI has been isolated from the venom of the cone snail Conus imperialis. α-conotoxin IMI acts on postsynaptic membranes, and binds onto and inhibits nicotinic acetylcholine receptors (nAChR). This toxin blocks mammalian neuronal nAChRs (α3/ß2 > α7 > α3/ß4). It has no effect on nAChRs composed of α2/ß2, α3/ß2, α4/ß2, α2/ß4, α3/ß4, or α4/ß4 subunits. α-conotoxins IMI acts independently of voltage value. This toxin is highly active against the neuromuscular receptor in frog.
Product Specification
AA sequence: H-Gly-Cys2-Cys3-Ser-Asp-Pro-Arg-Cys8-Ala-Trp-Arg-Cys12-NH2
(Disulfide bonds between Cys2-Cys8 and Cys3-Cys12)
Length (aa): 12
Formula: C52H78N20O15S4
Molecular Weight: 1352.92 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: [156467-85-5]
Source: Synthetic
Purity rate: > 95 %
Price & Quantities
- 500 µg : 195 €
- 1 mg : 330 €
Other quantities available upon request
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References
- Ellison, M., et al. (2003) Alpha-conotoxins ImI and ImII. Similar alpha 7 nicotinic receptor antagonists act at different sites, J Biol Chem 278, 757-764. PubMed link
- Rogers, J. P., et al. (2000) Structure-activity relationships in a peptidic alpha7 nicotinic acetylcholine receptor antagonist, J Mol Biol 304, 911-926. PubMed link
- Johnson, D. S., et al. (1995) alpha-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric alpha 7 and alpha 9 receptors, Mol Pharmacol 48, 194-199. PubMed link
- McIntosh, J. M., et al. (1994) A nicotinic acetylcholine receptor ligand of unique specificity, alpha-conotoxin ImI, J Biol Chem 269, 16733-16739. PubMed link