Conantokin G 
Catalog N : 08CON009
Conantokin G: toxin properties
Conantokin G has been isolated from the venom of the cone Conus geographus. This toxin selectively inhibits NR2B sub units of N-methyl-D-aspartate (NMDA) receptor-mediated calcium influx in central nervous system neurons. Conantokin G induces sleep-like symptoms in young mice and hyperactivity in older mice (SERT). This compound is currently being evaluated in phase II clinical trials under the name CGX-1007 by Cognetix Inc. It has been shown to be an effective antiepileptic agent in several animal models of seizures.
Product Specification
AA sequence: Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH2
Length (aa): 17
Formula: C88H138N26O44
Molecular Weight: 2264.23 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: [93438-65-4]
Source: Synthetic
Purity rate: > 97 %
Price & Quantities
- 500 µg : 110 €
- 1 mg : 190 €
Other quantities available upon request
___________________________________________________________________________
References
- Malmberg, A. B., Gilbert, H., McCabe, R. T., and Basbaum, A. I. (2003) Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T, Pain 101, 109-116.
- Klein, R. C., Prorok, M., Galdzicki, Z., and Castellino, F. J. (2001) The amino acid residue at sequence position 5 in the conantokin peptides partially governs subunit-selective antagonism of recombinant N-methyl-D-aspartate receptors, J Biol Chem 276, 26860-26867.
- Blandl, T., Warder, S. E., Prorok, M., and Castellino, F. J. (1999) Binding of cations to individual gamma-carboxyglutamate residues of conantokin-G and conantokin-T, J Pept Res 53, 453-464.