α-Conotoxin GI
Catalog N : 08CON005
α-conotoxin GI: toxin properties
α-conotoxin GI has been isolated from the venom of the cone snail Conus geographus. This conotoxin acts on postsynaptic membranes, which bind to the nicotinic acetylcholine receptor (nAChR). It Inhibits nAChR currents. The highest affinity site for Cis the α/δ site on mouse muscle-derived BC3H-1 receptor, and the other site (α/γ site) on nicotinic receptors from Torpedo californica electric organ.
Product Specification
AA sequence: Glu-Cys2-Cys3-Asn-Pro-Ala-Cys7-Gly-Arg-His-Tyr-Ser-Cys13-NH2
(Disulfide bonds between Cys2-Cys7, Cys3-Cys13)
Length (aa): 13
Formula: C55H80N20O18S4
Molecular Weight: 1437.61 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: [76862-65-2]
Source: Synthetic
Purity rate: > 95 %
Price & Quantities
- 500 µg : 135 €
- 1 mg : 225 €
Other quantities available upon request
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References
- Groebe, D. R., et al. (1997) Determinants involved in the affinity of alpha-conotoxins GI and SI for the muscle subtype of nicotinic acetylcholine receptors, Biochemistry 36, 6469-6474. PubMed link