E-mail Print PDF

ω CONOTOXIN SO-3-conotoxin_so-3

 

Catalog N : 08CON013

ω-conotoxins SO-3: toxin properties

ω-conotoxins act at presynaptic membranes, they bind and block voltage-sensitive calcium channels (VSCC). This peptide selectively targets N-type voltage-sensitive calcium channels. It has no effect on R-type calcium currents, voltage-sensitive sodium currents, delayed rectifier potassium currents and transient outward potassium currents. It displays an analgesic potency similar to MVIIA in a range of acute and chronic pain models in rodents, but has less adverse effects compared with identical dosages of MVIIA injected intrathecally.

Product Specification

AA sequence: H-Cys1-Lys-Ala-Ala-Gly-Lys-Pro-Cys8-Ser-Arg-Ile-Ala-Tyr-Asn-Cys15-Cys16-Thr-Gly-Ser-Cys20-Arg-Ser-Gly-Lys-Cys25-NH2
(Disulfide bonds between Cys1-Cys16, Cys8-Cys20 and Cys15-Cys25)
Length (aa): 25
Formula: C100H165N35O32S6
Molecular Weight: 2567.07 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number:
Source: Synthetic
Purity rate: > 97 %

Price & Quantities


  • 100 µg : 200 €
  • 500 µg : 700 €
  • 1 mg : 1190 €

Other quantities available upon request

Related products

ω-conotoxin GVIA

ω-conotoxin MVIIC

ω-agatoxin IVA

ω-conotoxin MVIIA

SNX482

___________________________________________________________________________

References

  • Wen, L., Yang, S., Qiao, H., Liu, Z., Zhou, W., Zhang, Y., and Huang, P. (2005) SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons, Br J Pharmacol 145, 728-739.
  • Dai, Q., Liu, F., Zhou, Y., Lu, B., Yu, F., and Huang, P. (2003) The synthesis of SO-3, a conopeptide with high analgesic activity derived from Conus striatus, J Nat Prod 66, 1276-1279.
  • Li, Z., He, X. P., Xie, Z. P., Dai, Q. Y., and Huang, P. T. (2003) Effect of new O-superfamily conotoxin SO3 on sodium and potassium currents of cultured hippocampal neurons, Brain Res 965, 155-158.

ADD_WISH