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Chlorotoxin chlorotoxin

 

Catalog N : 08CHL001


Chlorotoxin: toxin properties

Chlorotoxin is a neurotoxin that was originally isolated from the venom of Leiurus quinquestriatus. Chlorotoxin binds to Cl- channels (small conductance epithelial chloride channels) in the brain and spinal cord and inhibits Cl- influx. Chlorotoxin most probably acts as a specific blocker, although residues both inside and outside of the pore region of the Cl- channels participate in chlorotoxin binding.

Product Specification

AA sequence: H-Met-Cys2-Met-Pro-Cys5-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys16-Asp-Asp-Cys19-Cys20-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys28-Tyr-Gly-Pro-Gln-Cys33-Leu-Cys35-Arg-NH2
(Disulfide bonds between Cys2-Cys19, Cys5-Cys28, Cys16-Cys33 and Cys20-Cys35)
Length (aa): 36
Formula: C158H249N53O47S11
Molecular Weight: 3995.8 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: [163515-35-3]
Source: Synthetic

Price and Quantities

  • 100 µg : 140 €
  • 200 µg : 240 €
  • 500 µg : 350 €
  • 1 mg : 595 €

Other quantities available upon request

 Related product

 GaTx2

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References 

  • Debin JA, et al. Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion, Am. J. Physiol, 1993, 264, C361-C369. PubMed link
  • Soroceanu L. Modulation of glioma cell migration and invasion using Cl(-) and K(+) ion channel blockers. J Neurosci. 1999 Jul 15;19(14):5942-54. PubMed link
  • Lyons SA. Chlorotoxin, a scorpion-derived peptide, specifically binds to gliomas and tumors of neuroectodermal origin. Glia 2002 Aug;39(2):162-73. PubMed link

     

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