GaTx2

GaTx2: Toxin Properties

GaTx2 (gating modifier of anion channels 2) was isolated from the venom of Leiurus quinquestriatus hebraeus. GaTx2 is the most potent peptide inhibitor of ClC-2 chloride channel ever described. K_d value is close to 20 pM. GaTx2 slows ClC-2 activation but without altering channel conductance. The effect is voltage-dependent. This inhibitory effect was highlighted on rabbit ClC-2 channels expressed in oocytes. It has no effect on ClC-0, ClC-1, ClC-3, ClC-4, CFTR, GABA_C, Xenopus Cl_Ca, Shaker B or Kv1.2 channels. Structurally, GaTx2 is composed of two β-strands and one α-helix. This peptide is also called Leiuropeptide II. Bears 89, 93 and 96% identity with OdK1, neurotoxin PO1 and leiuropeptide III, respectively.

Product Specifications

AA sequence: H-Val-Ser-Cys³-Glu-Asp-Cys⁶-Pro-Asp-His-Cys¹⁰-Ser-Thr-Gln-Lys-Ala-Arg-Ala-Lys-Cys¹⁹-Asp-Asn-Asp-Lys-Cys²⁴-Val-Cys²⁶-Glu-Pro-Ile-OH
(Disulfide bonds between Cys³-Cys¹⁹, Cys⁶-Cys²⁴, and Cys¹⁰-Cys²⁶)
Length (aa): 29
Formula: C₁₂₅H₁₉₉N₃₉O₄₇S₆
Molecular Weight: 3191.25 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: not available
Source: Synthetic

Price & Quantities

• 100 µg : 300 €
• 500µg : 750 €
• 1 mg : 1275 €

Other quantities available upon request

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Related product

             Chlorotoxin

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References

• Thompson CH, Olivetti PR, Fuller MD, Freeman CS, McMaster D, French RJ, Pohl J, Kubanek J, McCarty NA. (2009) Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels. J Biol Chem 284(38):26051-62. PubMed link

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