E-mail Print

Why Smartox?


Tap into Smartox’s expertise to drive your research forward

Smartox Biotechnology is specialized in the chemical manufacturing of peptide toxins and other kind of cystein-rich peptides.

With extensive knowledge acquired in the chemical synthesis of peptides, the solubilization of hydrophobic peptides, the folding of linear peptides, the purification process and analytical techniques, Smartox is able to manufacture complex peptides ensuring a high purity rate and a high level of reproducibility between batches over short periods of time.

hplc_profile_agatoxin HLPC profile of ω-agatoxin IVA (48 amino-acids, 4 disulfide-bridges)
 
Column: 4µm
Purity rate > 98%

Inhibitory activity of Smartox's APETx2 toxin on ASIC3 expressed in CHO
APETx2

M. Blanchard, L. Rash, S. Kellenberger, Br J Pharmacol

Furthermore, this know-how allows us to customize complex peptides with a wide range of options (fluorescent labelling, Qdot, non natural amino-acids, PEG, etc.).

Fluorescent labeling of Maurocalcine with Cy5

Maurocalcine is a 33 amino acids peptide, 3 disulfide bridges 

 MCa-fluo
C. Poillot, et al., JBC
protxbiot HLPC profile of Biotinyl-ProTx-II (30 amino acids,
3 disulfide-bridges)

Column: 4µm
Purity rate: > 90 %

Smartox's scientific publications

  • d-Maurocalcine, a Pharmacologically Inert Efficient Cell-penetrating Peptide Analogue. J Biol Chem 2010. PubMed link
  • Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents. J Ethnopharmacol 2012. PubMed link
  • Cell Penetration Properties of a Highly Efficient Mini Maurocalcine Peptide. Pharmaceuticals 2013.
  • Small Efficient Cell-penetrating Peptides Derived from Scorpion Toxin Maurocalcine. J Biol Chem 2012. PubMed link

Citations

  • GaTx2: Eric E, et al. (2013) Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia. Am J Physiol Lung Cell Mol Physiol. PubMed
  • Huwentoxin IV, APETx2: Peigneur S, et al. (2012) A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins. FASEB J. PubMed link
  • APETx2: Blanchard MG, Rash LD, Kellenberger S. (2011) Inhibition of voltage-gated Na(+) currents in sensory neurons by the sea anemone toxin APETx2. Br J Pharmacol. PubMed link
  • APETx2: Tsuchimochi H, Yamauchi K, McCord JL, Kaufman MP. (2011) Blockade of Acid Sensing Ion Channels Attenuates the Augmented Exercise Pressor Reflex in Rats with Chronic Femoral Artery Occlusion. J Physiol. PubMed link

Contact us for more details.