Huwentoxin I

Huwentoxin I: toxin properties

Huwentoxin I is a neurotoxin that was originally isolated from Haplopelma schmidti (Chinese bird spider) (Ornithoctonus huwenum). This toxin selectively inhibits N-type calcium channels and has only a very weak effect on L-type calcium channels. It has virtually no effect on muscle sodium channels but is a potent inhibitor of neuronal TTX-sensitive channels, especially Nav1.7.

Product Specification

AA sequence: H-Ala-Cys²-Lys-Gly-Val-Phe-Asp-Ala-Cys⁹-Thr-Pro-Gly-Lys-Asn-Glu-Cys¹⁶-Cys¹⁷-Pro-Asn-Arg-Val-Cys²²-Ser-Asp-Lys-His-Lys-Trp-Cys²⁶-Lys-Trp-Lys-Leu-OH
(Disulfide bonds between Cys²-Cys¹⁷, Cys⁹-Cys²² and Cys¹⁶-Cys²⁹ )
Length (aa): 33
Formula: C₁₆₈H₂₅₀N₄₆O₄₁S₆
Molecular Weight: 3751.77 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number:
Source: Synthetic
Purity rate: > 97 %

Price & Quantities

• 100 µg : 200 €
• 500 µg : 700 €
• 1 mg : 1190 €

Other quantities available upon request

___________________________________________________________________________

References

• Wang M, et al. (2007) The cross channel activities of spider neurotoxin huwentoxin-I on rat dorsal root ganglion neurons. Biochem Biophys Res Commun. 2007 Jun 8;357(3):579-83
• Wang YR, et al. (2007) Effect of Huwentoxin-I on the Fas and TNF apoptosis pathway in the hippocampus of rat with global cerebral ischemia. Toxicon. 2007 Dec 15;50(8):1085-94. Epub 2007 Aug 7.
• Peng, K., et al. (2001) The effect of Huwentoxin-I on Ca(2+) channels in differentiated NG108-15 cells, a patch-clamp study, Toxicon 39, 491-498.
• Liang, S. P., et al. (2000) The presynaptic activity of huwentoxin-I, a neurotoxin from the venom of the chinese bird spider Selenocosmia huwena, Toxicon 38, 1237-1246.
• Zhou, P. A., et al. (1997) Blockade of neuromuscular transmission by huwentoxin-I, purified from the venom of the Chinese bird spider Selenocosmia huwena, Toxicon 35, 39-45.
• Liang, S. P., et al. (1993) Properties and amino acid sequence of huwentoxin-I, a neurotoxin purified from the venom of the Chinese bird spider Selenocosmia huwena, Toxicon 31, 969-978.

ADD_WISH