α Conotoxin GID
Catalog N : 08CON004
α-conotoxin GID: toxin properties
α-conotoxin GID has been isolated from the venom of the cone snail Conus geographus. This conotoxin acts on postsynaptic membranes. It inhibits their bind to the nicotinic acetylcholine receptors (nAChR) by binding onto them themselves. This toxin reversibly blocks nAChRs (α3/ß2 = α7 > α4/ß2).
Product Specification
AA sequence: Ile-Arg-Asp-Gla-Cys5-Cys6-Ser-Asn-Pro-Ala-Cys11-Arg-Val-Asn-Asn-Hyp-His-Val-Cys19-OH
(Disulfide bonds between Cys5-Cys11, Cys6-Cys19)
Length (aa): 19
Formula: C84H131N30O31S4
Molecular Weight: 2185.42 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: [92137-82-1]
Source: Synthetic
Purity rate: > 95 %
Price & Quantities
- 100 µg : 230 €
- 500 µg : 575 €
Other quantities available upon request
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References
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Nicke, A., Loughnan, M. L., Millard, E. L., Alewood, P. F., Adams, D. J., Daly, N. L., Craik, D. J., and Lewis, R. J. (2003) Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence, J Biol Chem 278, 3137-3144.