ADWX-1

ADWX-1 inhibits Kv1.3 channel with a high affinity and selectivity (IC50=1.89 pM)

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Leiurotoxin 1

Leuirotoxin binds to the SK channels (small conductance Ca2+-activated K+ channels)

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ShK

This toxin blocks Kv1.3 channel with 11pM.

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Apamin

Apamin binds to and inhibits the SK channels (small conductance Ca2+-activated K+ channels) in the brain and spinal cord.

 

Kaliotoxin-1

Kaliotoxin-1 is a selective inhibitor of BK channels

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Iberiotoxin


Iberiotoxin selectively inhibits Maxi-K channels

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Tamapin

Tamapin binds to small conductance Ca2+-activated K+ channels (SK channels)

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Margatoxin

This toxin is a potent selective inhibitor of voltage-dependent potassium channels such as Kv1.3.

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Tertiapin-Q

Tertiapin Q blocks the inwardly rectifying Kir1.1and Kir3.1/3.4 potassium channels

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Charybdotoxin

Charybdotoxin blocks voltage gated and Ca2+ activated K+ channels.

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Guangxitoxin 1E

Guangxitoxin 1E: . GxTx-1E inhibits Kv2.1 with an IC50 value of 1 nM and Kv2.2 with an IC50 value of 3 nM.

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HsTx1

It is one of the most potent toxins active on Kv1.3 channels (Kd close to 10 pM).

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Maurotoxin

Maurotoxin inhibits Kv1.1, Kv1.2, Kv1.3 (preferentially Kv1.2) and apamin sensitive SK channels

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