ShK (Stichodactyla toxin)
Catalog N : 08SHK001
ShK: toxin properties
ShK (Stichodactyla toxin) has been isolated from the venom of the Carribean sea anemone Stoichactis helianthus. This toxin inhibits voltage-dependent potassium channels. It blocks Kv1.3 (KCNA3) potently and also Kv1.1 (KCNA1), Kv1.4 (KCNA4), and Kv1.6 (KCNA6) respectively with 11 pM,16 pM and 165 pM.
Product Specification
AA sequence: H-Arg-Ser-Cys3-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys12-Thr-Ala-Phe-Gln-Cys17-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys28-Arg-Lys-Thr-Cys32-Gly-Thr-Cys35-OH
(Disulfide bonds between Cys3-Cys35, Cys12-Cys28 and Cys17-Cys32)
Length (aa): 35
Formula: C169H274N54O48S7
Molecular Weight: 4054.85 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: not available
Source: Synthetic
Purity rate: > 97%
Price & Quantities
- 100 µg : 200 €
- 500 µg : 875 €
Other quantities available upon request
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References
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Tudor, J. E., et al. (1996) Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone, Nat Struct Biol 3, 317-320.
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Pennington, M. W., et al. (1995) Chemical synthesis and characterization of ShK toxin: a potent potassium channel inhibitor from a sea anemone, Int J Pept Protein Res 46, 354-358.
- Castaneda, O., et al. (1995) Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus, Toxicon 33, 603-613.