Hemitoxin

 
  
Hemitoxin: toxin properties

Hemitoxin has been isolated from the venom of the scorpion Hemiscorpius lepturus. This toxin blocks rat voltage-gated potassium channels Kv1.1 (KCNA1), Kv1.2 (KCNA2) and Kv1.3 (KCNA3) expressed in Xenopus oocytes. IC₅₀ is 13 nM, 16 nM and 2 nm for the channels Kv1.1, Kv1.2 and Kv1.3.

Product Specification

AA sequence: H-Ile-Lys-Cys³-Thr-Leu-Ser-Lys-Asp-Cys⁹-Tyr-Ser-Pro-Cys¹³-Lys-Lys-Glu-Thr-Gly-Cys¹⁹-Pro-Arg-Ala-Lys-Cys²⁴-Ile-Asn-Arg-Asn-Cys²⁹-Lys-Cys³¹-Tyr-Gly-Cys³⁴-Ser-NH₂
(Presumed disulfide bonds between Cys³-Cys²⁴, Cys⁹-Cys ²⁹, Cys¹³-Cys³¹ and Cys¹⁹-Cys³⁴)
Length (aa): 35
Formula: C₁₅₉H₂₆₀N₅₀O₄₂S₇
Molecular Weight: 3896.66 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number:
Source: Synthetic
Purity rate: > 90%

Price & Quantities

• 50 µg : 210 €
• 100 µg : 350 €
• 500 µg : 875 €

Other quantities available upon request

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References

• Srairi-Abid, N., Shahbazzadeh, D., Chatti, I., Mlayah-Bellalouna, S., Mejdoub, H., Borchani, L., Benkhalifa, R., Akbari, A., and El Ayeb, M. (2008) Hemitoxin, the first potassium channel toxin from the venom of the Iranian scorpion Hemiscorpius lepturus, FEBS J 275, 4641-4650.

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