Leiurotoxin 1
Toxin properties
Leiurotoxin 1 (scyllatoxin) is a neurotoxin that was originally isolated from Leiurus quinquestriatus hebraeus. Leuirotoxin binds to the SK channels (small conductance Ca2+-activated K+ channels) in the brain and spinal cord and inhibits them.
Product specifications
AA sequence: H-Ala-Phe-Cys3-Asn-Leu-Arg-Met-Cys8-Gln-Leu-Ser-Cys12-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys21-Ile-Gly-Asp-Lys-Cys26-Glu-Cys28-Val-Lys-His-NH2
(Disulfide bonds between Cys3-Cys21, Cys8-Cys 26 and Cys12-Cys28)
Length (aa) : 31
Formula: C142H237N45O39S7
Molecular Weight: 3424.1 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: [116235-63-3]
Source: Synthetic
Purity rate: > 95%
Price & Quantities
| Reference # | Product name | Quantity (mg) | Price (€) | Ordering information |
| 10LEI001-00100 | Leiurotoxin 1 | 0.1 | 150 | |
| 10LEI001-00500 | Leiurotoxin 1 | 0.5 | 375 | |
| 10LEI001-01000 | Leiurotoxin 1 | 1 | 640 |
Other quantities available upon request
Related products
| Apamin | Charybdotoxin | Maurotoxin | Tamapin |
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References
- Chicchi, G. G.,et al. (1988) Purification and characterization of a unique, potent inhibitor of apamin binding from Leiurus quinquestriatus hebraeus venom, J Biol Chem.
- Auguste, P., et al. (1990) Leiurotoxin I (scyllatoxin), a peptide ligand for Ca2(+)-activated K+ channels. Chemical synthesis, radiolabeling, and receptor characterization, J Biol Chem.
- Martins, J. C., et al. (1990) Solution conformation of leiurotoxin I (scyllatoxin) by 1H nuclear magnetic resonance. Resonance assignment and secondary structure, FEBS Lett.