μ-Conotoxin PIIIA
Catalog N : 08CON006
Description
μ-Conotoxin PIIIA has been isolated from the venom of the cone Conus purpurascens. μ-Conotoxins bind and block site 1 of voltage-gated sodium channels. This toxin blocks the neuronal sodium channels Nav1.2 (SCN2A) and Nav1.7 (SCN9A). The peptide causes flaccid paralysis in both mice and fish.
Product Specification
AA sequence: H-pGlu-Arg-Leu-Cys4-Cys5-Gly-Phe-Hyp-Lys-Ser-Cys11-Arg-Ser-Arg-Gln-Cys16-Lys-Hyp-His-Arg-Cys21-Cys22-NH2
(Disulfide bonds between Cys4-Cys16, Cys5-Cys21 and Cys11-Cys22)
Length (aa): 22
Formula: C103H165N40O28S6
Molecular Weight: 2604.10 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number:
Source: Synthetic
Purity rate: > 97 %
Price & Quantities
- 100 µg : 200 €
- 500 µg : 500 €
- 1 mg : 850 €
Other quantities available upon request
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References
- Nielsen, K. J., et al. (2002) Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels, J Biol Chem 277, 27247-27255. PubMed link
- Safo, P., et al. (2000) Distinction among neuronal subtypes of voltage-activated sodium channels by mu-conotoxin PIIIA, J Neurosci 20, 76-80. PubMed link
- Shon, K. J., et al. (1998) mu-Conotoxin PIIIA, a new peptide for discriminating among tetrodotoxin-sensitive Na channel subtypes, J Neurosci 18, 4473-4481. PubMed link