Selective blocker of Cav2.3 channel

SNX-482 has been isolated from the venom of the Spider Hysterocrates gigas (African tarantula). SNX-482 modulates the R-type current associated with the class α1E calcium channel (Cav2.3 from the CACNA1E gene). SNX-482 antagonizes channel activation by inducing a depolarizing shift in the activation potential, thus preventing the channel from undergoing normal membrane depolarization. SNX-482 acts rapidly and maintains its effect.

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Product code: 08SNX001. Categories: , . Tags: , , .

AA sequence: Gly-Val-Asp-Lys-Ala-Gly-Cys7-Arg-Tyr-Met-Phe-Gly-Gly-Cys14-Ser-Val-Asn-Asp-Asp-Cys20-Cys21-Pro-Arg-Leu-Gly-Cys26-His-Ser-Leu-Phe-Ser-Tyr-Cys33-Ala-Trp-Asp-Leu-Thr-Phe-Ser-Asp-OH
Disulfide bonds: Cys7-Cys21, Cys14-Cys26 and Cys20-Cys33
Length (aa): 41
Formula: C192H274N52O60S7
Molecular Weight: 4496.42 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: 203460-30-4
Source: Synthetic
Purity rate: > 95 %






The Cav2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain

SNX482 selectively blocks P/Q Ca2+ channels and delays the inactivation of Na+ channels of chromaffin cells

Interaction of SNX482 with domains III and IV inhibits activation gating of alpha(1E) (Ca(V)2.3) calcium channels

Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas