SFET Meeting 2014

Meet Smartox at the annual meeting of the French Society of Toxinology.  The 22nd Meeting on Toxinology (RT22) will be held the december 10-11, 2014 at the Pasteur Institute and will be focused on : Toxins : New targets and New Functions.

The goal is to focus on studies highlighting the interaction of toxin with original targets or physiological functions.

SFET webiste


Wednesday, 10th December

9h00 – 9h10 : Welcome. Denis SERVENT (SFET President)

Session 1 | Toxins acting on Nervous system

Chairman: Cesare Montecucco & Jordi Molgó

  • 9h10 – 9h40 : Emmanuel BOURINET
    Ion Channel Science and Therapeutics. Institut de Génomique Fonctionnelle, Université de Montpellier, France
    Low-voltage gated calcium channels in pain pathways: from mechanisms to toxin identification
  • 9h40 – 10h10 : Eugene GRISHIN
    Laboratory of neuroreceptors and neuroregulators, Moscow, Russia
    Spider toxins active on purinergic P2X3 receptor
  • 10h10 – 10h30 : Christian LEGROS
    BNMI, UMR CNRS 6214 – UMR INSERM 1083, Angers, France
    Voltage-sensor probes as efficient tools to screen for new modulators of voltage-gated sodium channels
  • 10h30 – 11h00 : Yara CURY
    Laboratório Especial de Dor e Sinalização, Instituto Butantan, São Paulo, SP, Brazil
    Peripheral interactions between cannabinoid and opioid systems contribute to the antinociceptive effect of crotalphine

11h00 – 11h30 : Coffee break & Posters

  • 11h30 – 11h50 : Grazyna FAURE
    Institut Pasteur, Paris, France
    Crotoxin: New targets and new functions 
  • 11h50 – 12h10 : Killian L’HERONDELLE
    Université de Bretagne Occidentale, Brest, France
    Study of the involvement of itch mediators in the neuropeptide release induced by Pacific-Ciguatoxin-2 in a co-culture model of sensory neurons and keratinocytes
  • 12h10 – 12h30 : Laurent MARSOLLIER
    Centre de Recherche en Cancérologie Nantes Angers, Université d’Angers, France
    High content chemical and genetic screening reveal that analgesia in Buruli ulcer is induced by mycobacterial toxin targeting angiotensin pathways

12h45 – 14h30: Lunch & Posters

    • 14h30 – 15h00 : Cesare MONTECUCCO
      Department of Biomedical Sciences, University of Padova, Italy
      Animal presynaptic neurotoxins provide a relevant novel model of moto axon terminal degeneration followed by regeneration
    • 15h00 – 15h20 : Domenico AZARNIAN TEHRAN
      Department of Biomedical Sciences, University of Padova, Italy
      Thioredoxin and its reductase are present on synaptic vesicles and their inhibition prevents the paralysis induced by botulinum neurotoxin

Session 2 | Toxins acting on Gastro-Intestinal system

Chairman: Klaus Aktories & Emmanuel Lemichez

  • 15h20 – 15h50 : Klaus AKTORIES
    Institute for Experimental and Clinical Pharmacology and Toxicology, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany
    PaTox: A new bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins
  • 15h50 – 16h10 : Undine MECHOLD
    Institut Pasteur, Paris, France
    ExoY, a nucleotidyl cyclase toxin from Pseudomonas aeruginosa
  • 16h10 – 16h40 : Jean-Philippe NOUGAYREDE
    Inserm, UMR1043, Toulouse, France
    The genotoxin colibactin
  • 16h40 – 17h10 : Holger BARTH
    Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Ulm, Germany
    Role of host cell chaperones in cellular uptake of binary clostridial enterotoxins
  • 17h10 – 17h30 : Neetu GUPTA
    CEA, iBiTec-S, SIMOPRO, Gif sur Yvette, France
    Inhibitors of intracellular trafficking active against Shiga toxin and ricin

17h30 – 19h00: General Assembly of the SFET (SFET members)

Thursday, 11th December

Session 3 | Toxins acting on other systems, such as cardio-vascular, renal, immune systems

Chairman: Denise Tambourgi & Daniel Gillet

  • 9h00 – 9h30 : Diane BRINKMAN
    Australian Institute of Marine Science, Townsville, Australia
    Variable cardiovascular effects of Chironex fleckeri (box jellyfish) toxins
  • 9h30 – 10h00 : Nicolas GILLES

    Toxins, Receptors and Channels Group, CEA/ibiTecS/SIMOPRO. Gif sur Yvette. France
    Activity of Mambaquaretin toxin on kidney disease via its interaction with Vasopressin V2 receptor

  • 10h00 – 10h30 : Gérard LAMBEAU
    Institute of Cellular and Molecular Pharmacology. Université de Nice-Sophia-Antipolis, Valbonne, France
    The family of venom and mammalian sPLA2s : from toxic to therapeutic enzymes
  • 10h30 – 10h50 : Imen JRIDI
    Institut Pasteur of Tunis, Tunis, Tunisia
    Purification and characterization of two novel Hemiscorpius Lepturus scorpion venom-derived phospholipases A2 which inhibit angiogenesis in vitro

10h50 – 11h20: Coffee break & Posters

  • 11h20 – 11h50 : Denise TAMBOURGI
    Immunochemistry Laboratory, Butantan Institute, São Paulo, SP, Brazil
    Loxosceles Sphingomyelinase D induces leukocyte activation which is partially complement dependent: similarities to endotoxic shock
  • 11h50 – 12h10 : Gaëlle ZIMMERMANN-MEISSE
    Université de Strasbourg, EA7290, Strasbourg, France
    The staphylococcal Panton and Valentine Leukocidin and γ-haemolysin HlgC/HlgB share C5aR as a receptor, but operate diverse intracellular activities in human polymorphonuclear neutrophils

Session 4 | Miscellaneous

Chairman: Pascale Marchot & Daniel Ladant

  • 12h10 – 12h30 : Patrick JIMONET
    Sanofi, LGCR, Vitry sur Seine, France
    Venoms as source of active peptides: an attractive approach to drug challenging targets at Sanofi
  • 12h30 – 12h50: Michel DEGUELDRE
    University of Liege, Belgium
    Diversity in sequences, folds and pharmacological activities of toxins from four Conus venoms revealed by the combination of cutting-edge technologies of proteomics, transcriptomics and bioinformatics

13h00 – 15h00: Lunch & Posters

  • 15h00 – 15h20 : Emmanuel LEMICHEZ
    Centre Méditerranéen de Médecine Moléculaire, Université de Nice-Sophia Antipolis, France
    Transcellular tunnel dynamic: system model for studying actomyosin organization at newly curved plasma membrane
  • 15h20 – 15h40 : Alexandre CHENAL
    Institut Pasteur, Paris, France
    Deciphering protein membrane interactions involved in the translocation process of a bacterial toxin, the adenylate cyclase (CyaA) toxin from Bordetella pertussis
  • 15h40 – 16h00 : Daniel LAJOIE
    University of Arizona, Tucson, AZ, USA
    The chemistry and functional diversity of spider phospholipase D toxins
  • 16h00 – 16h20 : Romulo ARAOZ
    Laboratoire de Neurobiologie et Développement, CNRS, Gif sur Yvette, France
    Purification and characterization of hydrosoluble icthyotoxic compounds from the marine cyanobacterium Trichodesmium erythraeum collected in New Caledonia
  • 16h20 – 16h40 : Marion VERDONI
    Institut de Chimie Radicalaire, Faculté des Sciences et techniques, Université Aix-Marseille, Marseille, France
    Isolation and Characterization of a Natural Compound Extracted from Spider Venoms: a New Approach in Cosmetic to Treat Hyperpigmentation Disorders
  • 16h40 – 17h00 : Naoual OUKKACHE
    Institut Pasteur du Maroc, Casablanca, Morocco
    Characterization of two Moroccan scorpion venoms: proteomic analysis, neurotoxicity, myotoxicity and sensitivity to neutralization by commercial polyclonal antivenom 

17h00 Closure. Denis SERVENT (SFET President)

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