Modulators of tetrodotoxin S&R sodium channels

Smartox Biotechnology, specialized in animal peptide toxins synthesis, offers a wide range toxins that modulate ion channels. Among them, Smartox has developed a unique range of sodium channel blockers and activators including popular and innovative products. Nav channels are classified depending on their sensitivity to the widely used Tetrodotoxin (TTX) coming from puffer fish. Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 sub-types are known to be TTX-sensitive and Nav1.5, Nav1.8 and Nav1.9 are TTX-resistant.
Smartox Nav toxins

Tetrodotoxin sensitive channels
Subtype Nav1.1 Nav1.2Nav1.3Nav1.4Nav1.6Nav1.7
Blocker Phrixotoxin-3µ-conotoxin GIIIB
µ-conotoxin CnIIIC
µ-conotoxin PIIIA
Fluorescent ProTx-II
Huwentoxin IV
Fluorescent Huwentoxin-IV
Activator Hm1a OD1

Tetrodotoxin resistant channels
Subtype Nav1.5Nav1.8Nav1.9
Blocker Jingzhaotoxin-III ProTx-I
Fluorescent ProTx-I
Activator ATX-II

List of Smartox’s toxins and their preferential known Nav targets