Phrixotoxin-3

220 770 

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Selective blocker of Nav1.2

Phrixotoxin-3  (PaurTx3 or Beta-theraphotoxin-Ps1a) is a valuable pharmacological tool to study voltage-gated sodium channels. Phrixotoxin-3, originally issued from the venom of the tarantula phrixotrichus auratus, has been shown to inhibit Nav1.1, Nav1.2, Nav1.3, Nav1.4 and Nav1.5 with respective IC50 values of 610 nM, 0.6 nM, 42 nM, 288 nM and 72 nM. It is thus considered as one of the most potent and almost selective modulator of Nav1.2.

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Description

AA sequence: Asp-Cys2-Leu-Gly-Phe-Leu-Trp-Lys-Cys9-Asn-Pro-Ser-Asn-Asp-Lys-Cys16-Cys17-Arg-Pro-Asn-Leu-Val-Cys23-Ser-Arg-Lys-Asp-Lys-Trp-Cys30-Lys-Tyr-Gln-Ile-OH
Disulfide bridges: Cys2-Cys17, Cys9-Cys23, and Cys16-Cys30
Length (aa): 34
Formula: C171H245N53O47S6
Molecular Weight: 4059.9 Da
Appearance: White lyophilized solid
Solubility: water or saline buffer
CAS number: Not available
Source: Synthetic
Purity rate: > 97 %

ProTx-IProTx-IIProTx-II-Biotin
Huwentoxin-IVHuwentoxin-IHainantoxin-III
Hainantoxin-IVGsAF-2GsAF-1

Four Novel Tarantula Toxins as Selective Modulators of Voltage-Gated Sodium Channel Subtypes

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    Phrixotoxin-3

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