α-conotoxin-IMI

195 330 

α7 nAChR selective blocker

α-conotoxin IMI (alpha-conotoxin IMI) is a conopeptide that has been isolated from the venom of the cone snail Conus imperialis. α-conotoxin IMI acts on postsynaptic membranes, and binds onto and inhibits nicotinic acetylcholine receptors (nAChR). α-conotoxin IMI is a selective blocker of α7 homomeric nicotinic acetylcholine receptors (IC50 ~ 200 nM). It has no effect on nAChRs composed of α2/ß2, α3/ß2, α4/ß2, α2/ß4, α3/ß4, or α4/ß4 subunits. α-conotoxins IMI acts independently of voltage value. This toxin is highly active against the neuromuscular receptor in frog.

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Description

AA sequence: Gly-Cys2-Cys3-Ser-Asp-Pro-Arg-Cys8-Ala-Trp-Arg-Cys12-NH2
Disulfide bonds: Cys2-Cys8 and Cys3-Cys12
Length (aa): 12
Formula: C52H78N20O15S4
Molecular Weight: 1352.92 Da
Appearance: White lyophilized solid
Solubility: water or saline buffer
CAS number: [156467-85-5] Source: Synthetic
Purity rate: > 95 %

α-conotoxin-PeIAα-conotoxin-GID

 

Alpha-conotoxins ImI and ImII. Similar alpha 7 nicotinic receptor antagonists act at different sites

Structure-activity relationships in a peptidic alpha7 nicotinic acetylcholine receptor antagonist

alpha-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric alpha 7 and alpha 9 receptors

A nicotinic acetylcholine receptor ligand of unique specificity, alpha-conotoxin ImI

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    α-conotoxin-IMI

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