ρ-Da1a – AdTx1

110 300 

Selective antagonist of the alpha(1A)-adrenoceptor

AdTx1 (rho-Da1a – ρ-Da1a) is a 65 amino-acid peptide originally isolated from the venom of the green mamba, an African snake (Dendroaspis angusticep). AdTx1 is stabilized by four disulfide bridges and belongs to the family of the three-finger-fold peptide. AdTx1 has subnanomolar affinity (K(i)= 0.35 nM) and high specificity for the human alpha(1A)-adrenoceptor subtype and is 1000 times more potent on this subtype than on other adrenoceptor subtypes. AdTx1 is a potent relaxant of smooth muscles.

SKU: ADT001 Category: Tags: , , ,

Description

AA sequence: LTC3VTSKSIFGITTEDC17PDGQNLC24FKRRHYVVPKIYDSTRGC42AATC46PIPENYDSIHC57C58KTDKC63NE
Disulfide bonds: Cys3-Cys24, Cys17-Cys42, Cys46-Cys57, Cys58-Cys63
Length (aa): 65
Formula: C310H481N87O100S8
Molecular Weight (average): 7283.29 Da
Appearance: <hite lyophilized solid
Solubility: water and saline buffer
CAS number: not available
Source: synthetic
Purity rate: > 98 %

Isolation and pharmacological characterization of AdTx1, a natural peptide displaying specific insurmountable antagonism of the a1A-adrenoceptor
G protein-coupled receptors, an unexploited animal toxin targets: Exploration of green mamba venom for novel drug candidates active against adrenoceptors
Crystallization of recombinant green mamba ρ-Da1a toxin during a lyophilization procedure and its structure determination
Effects of ρ-Da1a a peptidic α(1) (A) -adrenoceptor antagonist in human isolated prostatic adenoma and anaesthetized rats
Orthosteric binding of ρ-Da1a, a natural peptide of snake venom interacting selectively with the α1A-adrenoceptor
Polypharmacology profiles and phylogenetic analysis of three-finger toxins from mamba venom: case of aminergic toxins

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    ρ-Da1a - AdTx1

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