ω-Conotoxin-MVIIA

100 $425 $

ω Conotoxin MVIIA, a potent blocker of Cav2.2

ω conotoxin MVIIA (omega conotoxin MVIIA) has been isolated from the venom of the cone Conus magus. Omega-conotoxins act at presynaptic membranes, they bind and block voltage-sensitive calcium channels (VSCC). ω conotoxin MVIIA blocks N-type voltage-gated calcium channels (Cav2.2/CACNA1B). ω conotoxin MVIIA is available as analgesic drug under the name Prialt®. It blocks acute pain in patients who no longer obtain relief from opiate drugs. It is 100 to 1.000 times more potent than morphine. This toxin blocks calcium channels and disables nerves that transmit pain signals.


Contact us

Change currency
Clear
Product code: 08CON001. Categories: , . Tags: , , .

AA sequence: Cys1-Lys-Gly-Lys-Gly-Ala-Lys-Cys8-Ser-Arg-Leu-Met-Tyr-Asp-Cys15-Cys16-Thr-Gly-Ser-Cys20-Arg-Ser-Gly-Lys-Cys25-NH2
Disulfide bonds: Cys1-Cys16, Cys8-Cys20 and Cys15-Cys25
Length (aa): 25
Formula: C102H172N36O32S7
Molecular Weight: 2639.18 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: [107452-89-1] Source: Synthetic
Purity rate: > 97 %

Conotoxin-SO3

Conotoxin-MVIIC

SNX482

agatoxin-IVA

Conotoxin-GVIA

Ziconotide: neuronal calcium channel blocker for treating severe chronic pain

Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom