Selective blocker of Nav1.4 channels

µ-conotoxin CnIIIC is a conopeptide that has been isolated from the venom of the marine cone snail Conus consorsµ-conotoxin CnIIIC has been described to exhibit a myorelaxing effect through specific blockade of the skeletal muscle Nav1.4 channels (IC50 = 1.4 nM). µ-conotoxin CnIIIC also appears to block Nav1.2 channels (1 µM) and mildly Nav1.7. In contrast, Nav1.5 and Nav1.8 are insensitive to the action of the toxin. µ-conotoxin CnIIIC is also described to block the α3β2 nicotinic acetylcholine receptor (IC50= 450 nM) and to lesser extents the α7 and α4β2 subtypes and completely inhibits twitch tension in isolated mouse hemidiaphragms (IC50 = 150 nM). This peptide is a valuable tools to study Nav1.4 channels.

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Product code: N/A. Category: . Tag: .

AA sequence: Pyr-Gly-Cys3-Cys4-Asn-Gly-Pro-Lys-Gly-Cys10-Ser-Ser-Lys-Trp-Cys15-Arg-Asp-His-Ala-Arg-Cys21-Cys22-NH2 
Disulfide bonds: Cys3-Cys15, Cys4-Cys21 and Cys10-Cys22
Length (aa): 22
Formula: C92H141N35O28S6
Molecular Weight: 2375.8 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number:
Source: Synthetic
Purity rate: > 95 %
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A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors

Mechanism and molecular basis for the sodium channel subtype specificity of µ-conopeptide CnIIIC.