GsAF-2

200 950 

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Blocker of Nav1.1 / 1.2 / 1.3 / 1.4 / 1.6 / 1.7

GsAF-II (also termed Kappa-theraphotoxin-Gr2c, GsAF-2) was originally isolated from the venom of Grammostola rosea spider. GsAF-II peptide toxin has antinociceptive and antiarrhythmic effects in mammals. The peptide is reported to block the following voltage-gated sodium channels: Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 with IC50 values of, respectively, 5.7, 12, 24, 4, 6.6 and 1.3 µM. This peptide also blocks hERG1 with an IC50 value of 4.7 µM.

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Description

AA sequence: Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp-Glu-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Leu-Val-Cys21-Arg-Leu-Trp-Cys25-Lys-Lys-Lys-Ile-Glu-Trp-OH
Disulfide bonds: Cys2-Cys16, Cys9-Cys21, and Cys15-Cys25)
Length (aa): 31
Formula: C176H261N47O45S7
Molecular Weight:  3979.78 Da
Appearance: White lyophilized solid
Solubility: aqueous buffer
CAS number: not available
Source: Synthetic
Purity rate: > 98%

ProTx-IProTx-IIProTx-II-Biotin
Huwentoxin-IHuwentoxin-IVHainantoxin-III
Hainantoxin-IVJingzhaotoxin-IIIGsAF-1
Phrixotoxin-3μ-conotoxin-PIIIA
Target Promiscuity and Heterogeneous Effects of Tarantula Venom Peptides Affecting Na+ and K+ Ion Channels

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    GsAF-2

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