MT7 – Muscarinic Toxin 7

Blocker of M1-subtype of muscarinic receptor

Muscarinic toxin 7 (MT7 – m1-toxin 1) has been isolated from the venom of the green mamba (Dendroaspis Angusticeps). MT7 potently blocks M1-subtype of muscarinic acetylcholine receptors at a subnanomolar affintiy. Muscarinic acetylcholine receptors are G-protein coupled receptors that mediate the metabotropic effects of acetylcholine. M1-type muscarinic acetylcholine receptors are well known therapeutic targets to improve cognitive functions in patients with Alzheimer disease. Contrary to many ligands that target mAChRs (pirenzepine, carbamoylcholine chloride, 4-DAMP or atropine), MT7 is the most selective M1-subtype antagonist as it is about 10,000 times more selective for M1-subtype than other subtypes. MT7 toxin is an ideal tool to identify the muscarinic receptor subtype expression in tissues for example. MT7 toxin belongs to the three finger toxin family such as rho-Da1a.

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Product code: MTX007. Category: . Tag: .

AA sequence: LTC3VKSNSIWFPTSEDC17PDGQNLC24FKRWQYISPRMYDFTRGC42AATC46PKAEYRDVINC57C58GTDKC63NK
Disulfide bonds: Cys3-Cys24, Cys17-Cys42, Cys46-Cys57, Cys58-Cys63
Length (aa): 65
Formula: C322H484N90O98S9
Molecular Weight: 7472.53 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: not available
Source: synthetic
Purity rate: > 98%

Structural determinants for the interactions between muscarinic toxin 7 and muscarinic acetylcholine receptors

Molecular conversion of muscarinic Acetylcholine Receptor M5 to Muscarinic Toxin (MT7) binding protein

Different interaction between MT7 toxin and the human muscarinic M1 Receptor in its free san N-Methylscopolamine occupied states.

Muscarinic Toxin 7 selectivity is dictated by extracellular receptor loops

Effects of muscarinic toxins MT2 and MT7, from green mamba venom, on m1, m3 and m5 muscarinic receptors expressed in Chinese Hamster Ovary cells

Inhibition of acetylcholine muscarinic M1 receptor function by the M1-selective ligand muscarinic toxin 7 (MT-7)