149 605 


SK channels blocker

Scyllatoxin (Leiurotoxin-1) is a neurotoxin that was originally isolated from Leiurus quinquestriatus hebraeus. Scyllatoxin binds and blocks SK channels (small conductance Ca2+-activated K+ channels) in the brain and spinal cord and inhibits them.

Contact us


AA sequence: Ala-Phe-Cys3-Asn-Leu-Arg-Met-Cys8-Gln-Leu-Ser-Cys12-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys21-Ile-Gly-Asp-Lys-Cys26-Glu-Cys28-Val-Lys-His-NH2
Disulfide bonds between: Cys3-Cys21, Cys8-Cys 26 and Cys12-Cys28
Length (aa) : 31
Formula: C142H237N45O39S7
Molecular Weight: 3424.1 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: [116235-63-3] Source: Synthetic
Purity rate: > 95%

Effect of charybdotoxin and leiurotoxin I on potassium currents in bullfrog sympathetic ganglion and hippocampal neurons

An apamin- and scyllatoxin-insensitive isoform of the human SK3 channel

Leiurotoxin I, a scorpion toxin specific for Ca(2+)-activated K+ channels. Structure-activity analysis using synthetic analogs

Scyllatoxin, a blocker of Ca(2+)-activated K+ channels: structure-function relationships and brain localization of the binding sites

Purification and characterization of a unique, potent inhibitor of apamin binding from Leiurus quinquestriatus hebraeus venom

Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata


Sign Up to our Newsletter



    149 605 Quote request