Waglerin-1 blocks muscle nAChRs

Waglerin-1 (Wtx-1) is a peptide originally isolated from the venom of the Wagler’s pit viper (Trimeresurus wagleri). This 22 amino-acid peptide is a competitive antagonist of adult muscle nicotinic acetylcholine receptors. Waglerin-1 binds selectively to epsilon subunit of nAChR. Some studies have demonstrated that Waglerin-1 has an effect on ionotropic GABA receptors. It may potentiate or depress I(GABA) depending on the neurons. Some derivatives of Waglerin-1 are currently used in cosmetics to reduce wrinkles. The fluorescent derivative Waglerin-1-FAM can be use to explore the expression and function of the adult nAChR subtypes.

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Product code: WAG002. Category: . Tags: , , .

AA sequence:  FAM-Gly-Gly-Lys-Pro-Asp-Leu-Arg-Pro-Cys9-His-Pro-Pro-Cys13-His-Tyr-Ile-Pro-Arg-Pro-Lys-Pro-Arg-OH
Disulfide bonds: Cys9-Cys13
Length (aa): 22
Formula: C133H185N37O32S2
Molecular Weight: 2878.27 Da
CAS number: NA
Source: Synthetic
Fluorescent dye: FAM, 5(6)-carboxyfluorescein (λex 492, λem 517)





Peptide-toxin tools for probing the expression and function of fetal and adult subtypes of the nicotinic acetylcholine receptor

Conformational analysis of a toxic peptide from Trimeresurus wagleri which blocks the nicotinic acetylcholine receptor

Identification of residues at the alpha and epsilon subunit interfaces mediating species selectivity of Waglerin-1 for nicotinic acetylcholine receptors

Waglerin-1 selectively blocks the epsilon form of the muscle nicotinic acetylcholine receptor

Waglerin-1 inhibits GABA(A) current of neurons in the nucleus accumbens of neonatal rats. Brain Res

Waglerin-1 modulates gamma-aminobutyric acid activated current of murine hypothalamic neurons