187 935 


Maurocalcine, a potent agonist of ryanodine receptors

Maurocalcine, a component of the venom of Scorpio maurus palmatus, was discovered by Michel De Waard, co-founder of Smartox. Maurocalcine folds according to an inhibitor cysteine knot. Such as Imperatoxin A, Maurocalcine acts as a high affinity agonist of the type-1 ryanodine receptor expressed in skeletal muscles with an affinity in the 10 nM range. Maurocalcine induces an increase in channel opening probability accompanied by sudden transitions to long lasting subconductance states. Maurocalcine has also been characterized as a cell penetrating peptide and its pharmacological activity can be observed upon extracellular perfusion.


Maurocalcine ryanodine receptor activator of skeletal muscle myotubes


AA sequence: Gly-Asp-Cys3-Leu-Pro-His-Leu-Lys-Leu-Cys10-Lys-Glu-Asn-Lys-Asp-Cys16-Cys17-Ser-Lys-Lys-Cys21-Lys-Arg-Arg-Gly-Thr-Asn-Ile-Glu-Lys-Arg-Cys32-Arg-OH
Disulfide bonds: Cys3-Cys17, Cys10-Cys21 and Cys16-Cys32
Length (aa): 33
Formula: C156H260N56O46S6
Molecular Weight: 3858.8 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: not available
Source: Synthetic
Purity rate: > 98 %

Redox-sensitive stimulation of type-1 ryanodine receptors by the scorpion toxin maurocalcine. Cell Calcium

Maurocalcine interacts with the cardiac ryanodine receptor without inducing channel modification

Chemical synthesis and characterization of maurocalcine, a scorpion toxin that activates Ca(2+) release channel/ryanodine receptors

A new fold in the scorpion toxin family, associated with an activity on a ryanodine-sensitive calcium channel

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