Chlorotoxin

140 595 

Selective blocker of small conductance chloride channels

Chlorotoxin (Cltx) is a neurotoxin that was originally isolated from the venom of Leiurus quinquestriatus. Chlorotoxin is a specific ligand of glioma cellsChlorotoxin binds to Clchannels (small conductance epithelial chloride channels) in the brain and spinal cord and inhibits Cl influx. Chlorotoxin most probably acts as a specific blocker, although residues both inside and outside of the pore region of the Cl channels participate in chlorotoxin binding. It was demonstrated that chlorotoxin inhibits specifically the activity of matrix metalloproteinase-2 (MMP-2) without affecting MMP-1, MMP-3 and MMP-9. MMP-2 are upregulated in glioma cells and related cells making chlorotoxin a promising antitumoral drug and diagnosis tool.

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Description

AA sequence: Met-Cys2-Met-Pro-Cys5-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys16-Asp-Asp-Cys19-Cys20-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys28-Tyr-Gly-Pro-Gln-Cys33-Leu-Cys35-Arg-NH2
Disulfide bonds: Cys2-Cys19, Cys5-Cys28, Cys16-Cys33 and Cys20-Cys35
Length (aa): 36
Formula: C158H249N53O47S11
Molecular Weight: 3995.8 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: [163515-35-3] Source: Synthetic
Purity rate: > 95 %

GaTx2
Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2

Chlorotoxin, a scorpion-derived peptide, specifically binds to gliomas and tumors of neuroectodermal origin.

Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion

Modulation of glioma cell migration and invasion using Cl(-) and K(+) ion channel blockers

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    Chlorotoxin

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