Agitoxin-2

150 600 

Blocker of Kv1.1 and Kv1.3 channels

Agitoxin-2 is a potent and selective blocker of the Shaker type voltage-gated Kv1.3 and Kv1.1 channels. Agitoxin-2 inhibits Kv1.3 with an IC50 value of around 200 pM and Kv1.1 with an IC50 value of around 140 pM. This peptide toxin was originally isolated from the venom of the Israeli scorpion L. quinquestriatus hebraeus.

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Description

AA sequence: Gly-Val-Pro-Ile-Asn-Val-Ser-Cys8-Thr-Gly-Ser-Pro-Gln-Cys14-Ile-Lys-Pro-Cys18-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys28-Met-Asn-Arg-Lys-Cys33-His-Cys35-Thr-Pro-Lys-OH
Disulfide bonds: Cys8-Cys28; Cys14-Cys33; Cys18-Cys35
Length (aa): 38
Formula: C169H278N54O48S8
Molecular Weight: 4090.89 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: 168147-41-9
Source: Synthetic
Purity rate: > 97 %

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Recombinant Expression of Margatoxin and Agitoxin-2 in Pichia pastoris: An Efficient Method for production of KV1.3

Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom

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    Agitoxin-2

    150 600 Quote request