138 1980 


ATTO488-ProTx-II is a fluorescently labeled ProTx-II, a famous Nav1.7 blocker. The wild type ProTx-II blocks Nav1.7  with an IC50 value of around 300 pM, Nav1.2,  Nav1.5 and Nav1.6 with IC50 values of 41 nM, 79 nM and 26 nM respectively.

ATTO488-ProTx-II has been tested and its biological activity has been validated.

Nav1.7 protx-II fluorescent

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SKU: PTF004 Category: Tags: , , , , ,


AA sequence: Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp-Ser-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Met-Val-Cys21-Arg-Leu-Trp-Cys25-Lys-Lys-Lys-Leu-Trp-OH
Disulfide bonds: Cys2-Cys16, Cys9-Cys21, Cys15-Cys25
Length (aa): 30
ProTx-II formula: C168H250N46O41S8
ProTx-II Molecular Weight: 3826,66 g/mol
Source: Synthetic
Purity rate: > 95 %
ATTO488: λex 500nm , λem 520nm
Stoichiometry: 1:1

Fluorescent- and tagged-protoxin II peptides: potent markers of the Nav1.7 channel pain target

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