AA sequence: Tyr-Pro-Phe-Pro-NH2
Length (aa): 4
Formula: C28H35N5O5
Molecular weight: 521.64 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: 87777-29-5
Source: Synthetic
Purity rate: > 97 %
Morphiceptin
Agonist of µ-opoid receptor
Synonym : ß-casomorphin (1-4) amide
Morphiceptin is a four amino acid peptide derived from the ß-casomorphin, a protein fragment itself derived from the digestion of milk protein casein. It is one of the most selective agonist for µ-opoid receptors.
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Morphiceptin (NH4-tyr-pro-phe-pro-COHN2): a potent and specific agonist for morphine (mu) receptors
The synthetic peptide NH2-Tyr-Pro-Phe-Pro-CONH2 (morphiceptin), which is the amide of a fragment of the milk protein beta-casein, has morphinelike activities and is highly specific for morphine (mu) receptors but not for enkephalin (delta) receptors. It is as active as morphine in the guinea pig ileum but much less active in the mouse and rat vas deferens. The discovery of this specific morphine receptor ligand substantiates the hypothesis of multiple opiate receptors. The ligand, which may be of physiological significance since a very similar, or identical, activity can be detected in enzymatic digests of beta-casein, may prove useful for further investigation of the functions of opiate receptor subtypes.
Chang KJ et al. Morphiceptin (NH4-tyr-pro-phe-pro-COHN2): a potent and specific agonist for morphine (mu) receptors. Science. PMID: 6259732