Psalmotoxin-1 / PcTx1

149 638 


ASIC1a selective blocker

Psalmotoxin-1 (PcTx1, Pi-theraphotoxin-Pc1a) has been isolated from the venom of the Spider Psalmopoeus cambridgei (Trinidad chevron tarantula). PcTx1 is known to block potently (IC50 = 1 nM) and selectively the H+-gated sodium channel ASIC1a (acid-sensitive ion channel 1a). The blockage is rapid and reversible. PcTx1 can distinguish between the two ASIC1 splice variants ASIC1a and ASIC1b. PcTx1 loses its capacity to block ASIC1a as soon as this subunit is associated with another member of the family (ASIC2a or ASIC3). PcTx1 demonstrates an analgesic effect in acute and neuropathic pain models.

Recently quoted in Scientific reports

PcTx1 #13PCT001 ASIC channel blocker

Fig 1: effect of 30 nM PcTx1 #13PCT001 on ASIC1a expressed in oocytes. Inhibition is nearly complete at this concentration.

SKU: 13PCT001 Category: Tags: ,


AA sequence: Glu-Asp-Cys3-Ile-Pro-Lys-Trp-Lys-Gly-Cys10-Val-Asn-Arg-His-Gly-Asp-Cys17-Cys18-Glu-Gly-Leu-Glu-Cys23-Trp-Lys-Arg-Arg-Arg-Ser-Phe-Glu-Val-Cys33-Val-Pro-Lys-Thr-Pro-Lys-Thr-OH
Disulfide bonds: Cys3-Cys18, Cys10-Cys23 and Cys17-Cys33
Length (aa): 40
Formula: C200H312N62O57S6
Molecular Weight: 4690.82 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: not available
Source: Synthetic
Purity rate: > 98%

Heteromeric Acid-Sensing Ion Channels (ASICs) Composed of ASIC2b and ASIC1a Display Novel Channel Properties and Contribute to Acidosis-Induced Neuronal Death

Psalmotoxin-1 docking to human acid-sensing ion channel-1

A tarantula peptide against pain via ASIC1a channels and opioid mechanisms

Cation selectivity and inhibition of malignant glioma Na+ channels by Psalmotoxin 1

Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels

Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels

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    Psalmotoxin-1 / PcTx1

    149 638 Quote request