400 $1. 200 $

8xHis-ProTx-II, Nav1.7 selective blocker

ProTx-II (ProTx-2, Protoxin II) is a toxin that was originally isolated from Thrixopelma pruriens (Peruvian green velvet tarantula). ProTx-II inhibits both tetrodotoxin-sensitive and  tetrodotoxin-resistant voltage-gated sodium channels. ProTx-II inhibits activation by shifting the voltage-dependence of channel activation to more positive potentials. ProTx-II blocks Nav1.7  with an IC50 value of around 300 pM, Nav1.2 Nav1.5 and Nav1.6 with IC50 values of 41 nM, 79 nM and 26 nM respectively. It also acts on Cav3.1/CACNA1G and interacts more weakly with the related T-Type channel Cav3.2/CACNA1H but potently inhibits the L-type calcium channel Cav1.2/CACNA1C. ProTx-II blocks action potential propagation in nociceptors. 8xHis-ProTx-II is a polyhistidine tagged version of ProTx-II.

Recently quoted
Change currency
Product code: N/A. Category: . Tags: , , , , , , .

New Products

Ion channel blockers

View more

Toxin of the month – Free sample*

Each month, Smartox Biotechnology is offering a toxin for absolutely free*! These toxins are being introduced in sample sizes so that you can experiment how well they work!

January 2018: GaTx2

Discover GaTx2, a potent blocker of ClC2 channels

Ask a Free Sample

Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads

Evidence for multiple effects of ProTxII on activation gating in Na(V)1.5

ProTx-II, a selective inhibitor of Nav1.7 sodium channels, blocks action potential propagation in nociceptors

ProTx-I and ProTx-II: gating modifiers of voltage-gated sodium channels

Differential phospholipid binding by site 3 and site 4 toxins. Implications for structural variability between voltage-sensitive sodium channel domains

Two tarantula peptides inhibit activation of multiple sodium channels