Iberiotoxin

120 550 

Blocker of high conductance Ca2+-activated K+ channel

Iberiotoxin (IbTx) is a toxin that was originally isolated from Buthus tamulus scorpion venom. Iberiotoxin inhibits selectively the high conductance Ca2+-activated K+ channel (KCa1.1) at nanomolar concentrations (IC50 ~2 nM). This toxin does not affect other types of calcium-dependent or voltage-dependent K+ channels. Iberiotoxin is a valuable tool to study specifically Maxi-K channels.

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Iberiotoxin Bioassay

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Description

AA sequence: pGlu-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-GIu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-GIn-OH
Disulfide bridges: Cys7-Cys28, Cys13-Cys33, Cys17-Cys35
Length (aa): 37
Formula: C179H274N50O55S7
Molecular Weight: 4230.8 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: 129203-60-7
Source: Synthetic
Purity rate: > 95 %

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Effects of the novel BK (KCa 1.1) channel opener GoSlo-SR-5-130 are dependent on the presence of BKβ subunits.

Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus

Mechanism of iberiotoxin block of the large-conductance calcium-activated potassium channel from bovine aortic smooth muscle

High-conductance calcium-activated potassium channels; structure, pharmacology, and function

Use of toxins to study potassium channels

Mode of action of iberiotoxin, a potent blocker of the large conductance Ca(2+)-activated K+ channel

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    Iberiotoxin

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