alpha-cobratoxin

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α7 nicotinic acetylcholine receptor (nAChR) antagonist

α-cobratoxin (alpha-elapitoxin-Nk2a) has been isolated from the venom of the Naja kaouthia cobra snake. α-cobratoxin preferentially blocks muscular and neuronal α 7/CHRNA7 nicotinic acetylcholine receptor (Kd = 55 pM). α-cobratoxin is involved in paralysis by preventing acetylcholine binding to the nAChR. This toxin has shown to cause reduction of tumor growth in mice lung cancer.

Description

AA sequence: IRCFITPDIT SKDCPNGHVC YTKTWCDAFC SIRGKRVDLG CAATCPTVKT GVDIQCCSTD NCNPFPTRKR P
Disulfide bonds: Cys3-Cys20, Cys14-Cys41, Cys26-Cys30, Cys45-Cys56 and Cys57-Cys62
Length (aa): 71
Formula: C332H520N98O101S10
Molecular Weight: 7821.04 g/mol
Appearance: White lyophilized solid
Solubility: water or saline buffer
CAS number: 769933-79-1
Source: Synthetic
Purity rate: > 95 %

The refined crystal structure of alpha-cobratoxin from Naja naja siamensis at 2.4-A resolution

Inhibition of nonneuronal alpha7-nicotinic receptor for lung cancer treatment.

Spontaneous conformational change and toxin binding in alpha7 acetylcholine receptor: insight into channel activation and inhibition.

NMR-based binding screen and structural analysis of the complex formed between alpha-cobratoxin...

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    alpha-cobratoxin