μ-conotoxin-PIIIA

Blocker of Nav1.4 channels

μ-Conotoxin PIIIA (mu-conotoxin PIIIA) is a conotoxin that has been isolated from the venom of the cone Conus purpurascens. μ-conotoxin PIIIA  demonstrates a higher affinity for the mammalian muscle sodium channel  Nav1.4  (IC50  ~ 44 nM) than for the CNS Nav1.2 subtype (IC50  ~ 640  nm).  μ-Conotoxin PIIIA  blocks  more  irreversibly amphibian  muscle  sodium  channels  than mammalian ones.


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Product code: N/A. Category: . Tag: .

AA sequence: H-pGlu-Arg-Leu-Cys4-Cys5-Gly-Phe-Hyp-Lys-Ser-Cys11-Arg-Ser-Arg-Gln-Cys16-Lys-Hyp-His-Arg-Cys21-Cys22-NH2
(Disulfide bonds between Cys4-Cys16, Cys5-Cys21 and Cys11-Cys22)
Length (aa): 22
Formula: C103H165N40O28S6
Molecular Weight: 2604.10 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number:
Source: Synthetic
Purity rate: > 97 %

Conotoxin-CnIIIC

Conotoxin-GIIIB

Mechanism of μ-Conotoxin PIIIA Binding to the Voltage-Gated Na+ Channel NaV1.4

Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels

Distinction among neuronal subtypes of voltage-activated sodium channels by mu-conotoxin PIIIA

mu-Conotoxin PIIIA, a new peptide for discriminating among tetrodotoxin-sensitive Na channel subtypes