α-conotoxin-PeIA

65 210 

Discriminates between α9α10 and α7 nAChRs

α-conotoxin PeIA is a conotoxin that has been isolated from the venom of Conus pergrandisα-conotoxin PeIA discriminates between α9α10 and α7 nicotinic acetylcholine receptors (AChRs) with IC50 values of 7-50 nM (depending of the authors) and 1.8 µM, respectively. The toxin is also known to block α3β2 nicotinic AChRs (with an IC50 of 97 nM) and block voltage-gated N-type Ca2+ channels in rat DRG neurons with an IC50 of 1.1 nM. No significant inhibition of ACh-evoked currents for nicotinic α4β2 and muscle αβγδ AChRs by 1 µM α-conotoxin PeIA was observed. The action of α-conotoxin PeIA is fully reversible after washout of the peptide in the extracellular medium.

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Description

AA sequence: Gly-Cys2-Cys3-Ser-His-Pro-Ala-Cys8-Ser-Val-Asn-His-Pro-Glu-Leu-Cys16-NH2 
Disulfide bonds: Cys2-Cys8, Cys3-Cys16
Length (aa): 16
Formula: C65H98N22O21S4
Molecular Weight: 1651.9 Da
Appearance: White lyophilized solid
Solubility: water or saline buffer
CAS number: not available
Source: Synthetic
Purity rate: > 99 %

α-conotoxin-IMIα-conotoxin-GID
Structure and Activity of α-Conotoxin PeIA at Nicotinic Acetylcholine Receptor Subtypes and GABAB Receptor-coupled N-type Calcium Channels

A novel α-conotoxin, PeIA, cloned from Conus Pergrandis, discriminates between rat α9α10 and α7 nicotinic cholinergic receptor

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    α-conotoxin-PeIA

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