149 605 


NMB-1 (Noxious mechanosensation blocker 1) is an analogue of a peptide isolated from a marine conesnail. This 19 amino acid peptide has shown a 30 fold selectivity in inhibiting slowly adapting mechanically activated currents over rapidly adapting ones. It is an interesting tool to distinguish between RA and SA currents. NMB-1 significantly blocks SA currents at 1 µM in sensory neurons contrary to GsMTx4. Some results suggest that NMB-1 could also block mechanosensitive ion channels in cochlear hair cells at 5 µM.
Smartox Biotechnology is pleased to be the first company offering this research tool.

SKU: NMB001 Category:


AA sequence: Phe-Asn-Trp-Arg-Cys-Cys-Leu-Ile-Pro-Cys-Arg-Arg-Asn-His-Lys-Lys-Phe-Phe-Cys-NH2
Disulfide bonds: Cys5-Cys19 and Cys6-Cys10
Length (aa): 19
Formula: C111H164N36O21S4
Molecular Weight:  2467.03 Da
Appearance: White lyophilized solid
Solubility: aqueous buffer
CAS number: not available
Source: Synthetic
Purity rate: > 95 %

  • GsMTx4: selective blocker of mechanosentive ion channels

High-Threshold Mechanosensitive Ion Channels Blocked by a Novel Conopeptide Mediate Pressure-Evoked Pain

Molecular mechanisms of mechanotransduction in mammalian sensory neurons

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