α-conotoxin-GI

Blocks the α/δ site of the muscle-type nAChR

α-conotoxin GI (alpha-conotoxin GI) is a conopeptide that has been isolated from the venom of the cone snail Conus geographus. α-conotoxin GI is a competitive antagonist of the muscle-type nicotinic acetylcholine receptors (nAChR) such as  α-conotoxin MI or d-Turbocurarine.  α-conotoxin GI allows to distinguish between the two agonist sites as it binds 10,000-fold more tightly to the α/δ than to the α/γ site excepted in Torpedo which is the reverse.


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Product code: 08CON015. Category: . Tags: , , .

AA sequence: Glu-Cys2-Cys3-Asn-Pro-Ala-Cys7-Gly-Arg-His-Tyr-Ser-Cys13-NH2
Disulfide bonds: Cys2-Cys7, Cys3-Cys13
Length (aa): 13
Formula: C55H80N20O18S4
Molecular Weight: 1437.61 Da
Appearance: White lyophilized solid
Solubility: water or saline buffer
CAS number: [76862-65-2] Source: Synthetic
Purity rate: > 95 %

conotoxin-MI

Waglerin-1

Conotoxin-PrXA

Determinants involved in the affinity of alpha-conotoxins GI and SI for the muscle subtype of nicotinic acetylcholine receptors

Alpha-Conotoxin GI produces tetanic fade at the rat neuromuscular junction

Postsynaptic block of frog neuromuscular transmission by conotoxin GI

Peptides isolated from the venom of Conus geographus block neuromuscular transmission